Quick answer
Skin ages faster with sun exposure because fibroblasts, the cells that make collagen, are damaged. A 2026 meta-analysis of 39 studies found wrinkles reduced by about 20% on average with exosome-based therapies, and a double-blind trial with 372 patients found 64% improved their smile lines with fibroblasts versus 36% with placebo. At Longevity Clinic, the doctor reviews your photos before you travel and designs a protocol with fibroblasts, exosomes and peptides; the application takes about 45 minutes.
Fine lines, uneven tone, rough texture and loss of firmness are, for the most part, the result of sun exposure and time. Regenerative skin treatments aim to improve the quality of the skin, not to change your face.
What happens in the skin, at the cellular level
Fibroblasts are the cells in the dermis that make collagen and elastin. With age and UV exposure they produce less, and UV breaks down the collagen already there.
- Fibroblasts: applying them aims to replenish the cells that make collagen.
- Exosomes: vesicles that carry signals between cells; they can stimulate fibroblasts and calm skin inflammation.
- Bioactive peptides: small proteins that support the skin's repair processes.
What the trials show
- Exosomes: a 2026 meta-analysis of 39 studies found wrinkles reduced by about 20% on average, with better pigmentation, elasticity and texture.
- Fibroblasts: in a double-blind trial with 372 patients, 64% improved their smile lines versus 36% with placebo.
Full summaries: exosomes for wrinkles and photoaging and fibroblasts for smile lines.
How it works if you live in the U.S.
- Send your photos by WhatsApp or email.
- Free review and protocol with fibroblasts, exosomes and peptides, according to your skin.
- One trip for an application of about 45 minutes. Your advisor helps with your hotel in Veracruz.
- Remote follow-up with control photos.
Studies cited
Stack ER, et al. Aesthetic Surgery Journal
Clinical Advances in Exosome-Based Therapies for Aesthetic Medicine: A Systematic Review and Meta-analysis of Human Clinical Trials
Reported result: Facial wrinkles decreased by 20.2% on average (95% CI 15.3–25.2%). Pigmentation, elasticity, texture, redness and overall appearance improved by 14.7% to 23.4%.
Smith SR, et al. Dermatologic Surgery
A multicenter, double-blind, placebo-controlled trial of autologous fibroblast therapy for the treatment of nasolabial fold wrinkles
Reported result: At 6 months, blinded evaluators rated 64% of patients treated with fibroblasts as improved by at least one point, versus 36% with placebo (p < 0.001). Adverse events were generally mild.
Yen C, et al. Journal of Craniofacial Surgery
Radiofrequency Microneedling Combined With Topical Extracellular Vesicle Preparation for Facial Rejuvenation: A Randomized Split-Face Controlled Study
Reported result: At 12 weeks, the side treated with microneedling plus extracellular vesicles improved 3.32 points more on the wrinkle scale than the side with microneedling alone. Local reactions were mild and temporary.
Frequently asked questions
Can I fly home the same day?
Often yes, but some applications leave redness or mild swelling for a few hours or days. The doctor tells you what to expect beforehand so you can plan your flight.
What photos should I send?
Your face from the front and both sides, in natural light, without makeup or filters. Tell us what you'd like to improve, previous treatments and any medications.
How long do results last?
It varies between people. Sun protection every day is part of the treatment: without it, UV keeps damaging the fibroblasts and any improvement fades sooner.